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| Initiating Antiretroviral Therapy | |
Attached file: |
(Russian, 398.4 kb)
Initiating Antiretroviral Therapy
|
Link to document(s) | http://www.hivinsite.com/In... |
Author(s): | E. M. Kojic, C.J. Carpenter |
Document type: | Monographs, Reports, and Book Chapters |
Language: | English, Russian |
Original language of document: | English |
Primary area(s) of focus: | HIV/AIDS |
Secondary areas of focus: | Immunopathogenesis of HIV Infection |
Submited by: | Victor Stanilevskiy |
Date of entry: | June 24, 2006 |
| Combination antiretroviral regimens have revolutionized the treatment of HIV infection, which has resulted in dramatic reductions in morbidity, mortality, and health care utilization. Effective antiretroviral therapy (ART) consistently results in sustained suppression of HIV-1 RNA replication, resulting in gradual increases in CD4 T-lymphocyte count, sometimes to normal levels. ART does not eradicate the virus, as viral replication continues in lymphoid tissue despite suppressive treatment. However, durable suppression of viral replication and the accompanying increases in CD4 count, reverse HIV disease progression, even in persons with advanced HIV infection. It is now possible to achieve at least transient reversal of disease progression in almost all patients who have received no prior ART, as HIV strains present in these "treatment-naive" patients will be susceptible to available antiretroviral drugs. | |
Overall user rating: | Not yet reviewed |
